منابع مشابه
Drug interaction between sevelamer and cyclosporin.
Sir, Sevelamer hydrochloride is a calcium-free polymer licensed recently as a phosphate binder in haemodialysis (HD) patients. Its use is associated with a slower progression of coronary and aortic calcifications than the use of calciumbased binders in such patients [1]. Sevelamer not only binds phosphate but also bile acids, thereby reducing LDL cholesterol levels [2]. Whether this effect on t...
متن کاملCanine mammary carcinoma cell line are resistant to chemosensitizers: verapamil and cyclosporin A.
Cancer chemotherapy can fail in many ways. One of the most significant is the development of multiple drug resistance (MDR), which constitutes a serious clinical problem. The development of MDR relates to the expression of a major membrane pump, P-glycoprotein (P-gp). Thus, currently one of the goals of experimental and clinical oncology is to decrease its activity. So far, many different P-gp ...
متن کاملp170-dependent multidrug resistance. Restoring full sensitivity to idarubicin with verapamil and cyclosporin A derivatives.
BACKGROUND Cell sensitivity to anthracyclines and other drugs depends on several factors, including overexpression of a 170Kd transmembrane glycoprotein (P170) that enhances drug efflux from the cells. Since the result of treatment is negatively related to the expression of P170 in leukemia, malignant lymphoma and other tumors, it is important to investigate drugs and methods that can modify mu...
متن کاملCombined use of cyclosporin A and verapamil in modulating multidrug resistance in human leukemia cell lines.
This study describes the synergistic interaction of two biochemical modulators, cyclosporin A (CyA) and verapamil (Vp), in multidrug-resistant cells, the highly resistant and moderately resistant variants (CEM/VLB 1000 and CEM/VLB 100) of the parental drug-sensitive T-cell leukemia cell line CEM/CCRF. In the absence of either modulator, the 50% inhibitory concentration for Adriamycin in these c...
متن کاملChemosensitization to adriamycin by cyclosporin A and verapamil in human retinoblastoma cell lines.
The chemosensitizing effects of cyclosporin A and verapamil on the cytotoxicity of adriamycin were investigated using MTT assay against two human retinoblastoma cell lines, Y79 and WERI-Rb-1. Y79 and WERI-Rb-1 were totally resistant to doses up to 5.0 micrograms/ml of verapamil. Cyclosporin A inhibited the survival of Y79 and WERI-Rb-1 dose-dependently, however, the maximum inhibition at the hi...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1988
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1988.tb03321.x